Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02747h

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc01831a Click here for additional data file.

Disulfide bonds provide a bioactivatable connection with applications in imaging and therapy. The circulation stability and intracellular release of disulfides are problematically coupled in that increasing stability causes a corresponding decrease in cleavage and payload release. However, an antibody offers the potential for a reversible stabilization. We examined this by attaching a small mol...

Observing single nanoparticle events at the orifice of a nanopipet† †Electronic supplementary information (ESI) available: Experimental details, zeta potential distribution, finite-element simulations, CLSM, and equation derivation. See DOI: 10.1039/c6sc02241c Click here for additional data file.

Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01565h Click here for additional data file.

The characterization of protein-nanoparticle assemblies in solution remains a challenge. We demonstrate a technique based on a graphene microelectrode for structural-functional analysis of model systems composed of nanoparticles enclosed in open-pore and closed-pore ferritin molecules. The method readily resolves the difference in accessibility of the enclosed nanoparticle for charge transfer a...

Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00038f Click here for additional data file.

Increase of enzyme activity through specific covalent modification with fragments† †Electronic supplementary information (ESI) available: Description of the experimental methods, chemical synthesis and analysis, details of the results and supplementary figures and tables. See DOI: 10.1039/c7sc01966a Click here for additional data file.